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Vol. 14 No. 1
Bioanalytical Systems, Inc. / July 1995


Electrochemical Measurements with Interdigitated Array Microelectrodes (58k)
Thin film carbon electrodes are finally practical. Thus, one can now seriously explore bioanalytical applications of this fascinating technology. Yuzuru Iwasaki and Masao Morita of NTT review progress to date.

Why to Calculate,When to Use, andHow to Understand Curvature Measuresof Nonlinearity
Intrinsic and parameter-effect curvatures as measures of nonlinearity may help in evaluation of the acceptability of a particular physical model. M. Karolczak of Adam Mickiewicz University in Poznan, Poland discusses their significance and various aspects of their use in the analysis of experimental data. The relationships of quantitative measures of nonlinearity to Studentís t-values, parametersí correlation coefficients, confidence intervals, and model choice are indicated.

Capillary Electrophoresis/ Electrochemistry (58k)
Capillary separation techniques show great promise for bioanalytical chemistry. Their high plate count and compatibility with small volume samples are intriguing for microdialysates. Thomas J. O’Shea of Searle and Susan Lunte of Kansas University review the use of electrochemical detection for capillary electrophoresis.

Voltammetric Determination of Trace Concentrations of Metals in the Environment (48k)
Atomic spectroscopy dominates trace metal determinations in the environment. Nevertheless, electroanalytical chemistry is also used and should especially be considered for toxic heavy metals. Adrian Bott continues his educational series on electrochemistry.

Continuous Monitoring of Subcutaneous Glucose and Lactate Using Microdialysis with On-Line Enzyme Electrodes
Microdialysis is a continuous sampling technique. It is appropriate to consider whether some substances can be continuously sensed in the dialysate stream. This is a progress report for an ongoing project at BAS and E. Heller and Co.

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