|
Foreword
(6k)
Indiana is not normally a venue for scientific meetings, but the situation
is improving...
Attomole
Measurement of Labeled Compounds (76k)
George S. Jackson, Frank A. Rickey, Darren Hillegonds, Mary A. Rounds,
and David Elmore of the Purdue University PRIME Lab describe the analytical
capabilities of this ultrasensitive analytical technique and provide
an overview of biomedical applications that have used AMS.
Accelerator mass spectrometry (AMS) is an ultrasensitive analytical
technique for measuring rare nuclides such as 14C, 26Al, and 41Ca.
The unique analytical capabilities of AMS allow long-term biological
studies that can not be performed with other methods. This paper describes
the analytical capabilities of this technique and provides an overview
of biomedical applications that have used AMS including some of the
work under way at the Purdue Rare Isotope Measurement Laboratory (PRIME
Lab).
Batch
Measurements Using the BAS-Zahner IM6 and IM6e Impedance Analyzers (35k)
Adrian W. Bott discusses the various functions of the IM6 and IM6e impedance
analyzers that are used to set up a series of experiments, either on
a single cell or on multiple cells.
Searching
for Chemical Information on the WWW (32k)
Lou
Coury will discuss a few Internet literature sites that are used by
scientists here at BAS in their daily work of providing scientific services,
contract research, new equipment and software to the scientific community.
The amount of chemical information available for free on the World Wide
Web (WWW) has experienced an explosive growth over the past few years.
In the early days of the web, search engines were inefficient and the
material they uncovered during scientific searches often tended to be
home pages of research groups presenting information that may not have
been subjected to the peer review process. By contrast, it is now possible
for anyone with an Internet connection and a web browser to gain free
access to the titles, authors, citations and abstracts for hundreds
of thousands of reviewed papers published in the primary literature.
This article will discuss a few sites that are accessible without charge
used by scientists here at BAS in their daily work of providing scientific
services, contract research, new equipment and software to the scientific
community.
Drug
Metabolism & Pharmacokinetics in Drug Discovery: A Primer for Bioanalytical
Chemists, Part I (57k)
In
Part I of a two-part series, Chandrani Gunaratna introduces the analytical
chemist to the fundamentals of drug metabolism.
In the face of advancing technology in combinatorial synthesis and high
throughput screening, the drug discovery process continues to evolve.
Preclinical drug metabolism and pharmacokinetics studies play a key
role in lead identification and optimization. This fast-paced development
process has imposed an enormous burden on the analytical chemist to
design faster and more sensitive assay techniques to aid the drug discovery
and development. This article, Part I of a two-part series introduces
the analytical chemist to the fundamentals of drug metabolism. Part
II of this series will discuss the pharmacokinetics aspects and how
drug metabolism data can be used to predict pharmacokinetic parameters.
Use of
a New Interface Cell for Off-Column CE-EC Determination of Catecholamine
Neurotransmitters (74k)
W. Russell Everett, Curtis Bohs, and Malonne I. Davies evaluate a new
prototype CE-EC interface design that uses standard BAS electrodes and
a bare fracture decoupler.
Analytical methods with high sensitivity and high selectivity for the
determination of neurotransmitters continue to be important in cases
such as monitoring the pharmacodynamics of neuroactive compounds. The
basal extracellular levels of some neurotransmitters and their metabolites
are low. Since microdialysis is widely used to obtain samples of brain
extracellular fluid, the sample volume available for analysis may be
only a few microliters. The small injection volume requirements of capillary
electrophoresis (CE) coupled with the limits of detection offered by
electrochemical detection (EC) make CE-EC a powerful tool for analysis
of neurotransmitters in microdialysis samples. Here we evaluate a new
prototype CE-EC interface design that uses standard BAS electrodes and
a bare fracture decoupler.
Products,
In the EC Literature, In the MD Literature, Miscellany (76k)
Products: PM-90e Series Pumps; new rotating disk electrode, the
RDE-2; latest version of the DigiSim simulation software for cyclic
voltammetry; y el modelo e2 epsilon.
In the EC Literature: Adrian Bott describes recent papers on
DNA sensing, cytochrome P450cam, polyoxometalates, and more.
In the MD Literature: James Gitzen of BAS discusses articles
on detecting catecholamines in cell culture media, and a role of glutamate
in ototoxicity.
Miscellany: EIS 2001 Symposium and Chemical Sensors Gordon Conference
information.
|
